The age of the Father has proved to be another of the factors affecting the likelihood of having children who later develop schizophrenia. A copy of a copy that later on will be copied and so on this is the story about the sperm. And the duplicating errors will probably be enriched by time.
It is becoming more and more obvious that not only the mother is important to the health of the child; we are getting increasingly aware of how the paternal age can affect the health of the children. The sperm does not seem to be as immortal and healthy as the producers tend to believe.
Sperm Quality & Schizophrenia
From the age 40-49 the risk is doubled, from 50 and up, there is a tripled that child later develops schizophrenia.
–
Reference:
Advancing Paternal Age and the Risk of Schizophrenia
Dolores Malaspina, MD, Susan Harlap, MBBS; Shmuel Fenner, MD, Dov Heiman, MPH, Daniella Nahon, BA; Your Feldman, MA, Ezra S. Susser, MD, PhD
Arch Gen Psychiatry. 2001, 58:361-367.
More information:
Sipos A, Rasmussen F, Harrison G, Tynelius P, Lewis G, Leon DA, Gunnell D.
Paternal age and schizophrenia: a population based cohort study.
BMJ. 2004 Nov 6;329(7474):1070. Epub 2004 Oct 22.
Från 50 och upp är risken trippel för att avkomman ska få schizofreni.
Quantum theory have long described the importance of the hydrogen binding network but the knowledge have been purely theoretical. Now we can see that water can switch dance partner About once every six picoseconds.
And that will be around 160 billion times a second.
If the water changes the way the molecules vibrate or just the axis of the molecules, then the major part of you will change. Can you ever believe that a change in the matter that make you, will change you?
“We found that the hydrogen bond breaks and reforms with an angular jump of about 50 degrees,” Gaffney said. “And that’s about what simulations performed by Michael Odelius suggested.”
The method used by Gaffney and his team to measure the bond lifetime and angle worked well for water and perchlorate, but is not possible with pure water; when all water molecules form the same hydrogen bonds, there is no way for the researchers to tell when they have switched partners. Fortunately, Gaffney said, all simulations seem to imply that the results found for salt water apply to pure water and a variety of aqueous solutions.
“This is exciting work,” Ji said. “To really understand water, the stuff that makes up more than half our bodies, we need to understand how these molecules move in a microscopic field. But it’s only with the recent development of ultrafast lasers that we’ve been able to measure the time scale of these small molecules.”
Will water ever make sense in your matter?
Hydrogen bonds (H-bonds) provide the intermolecular adhesion that dictates the unique properties of liquid water and aqueous solutions. Although H-bonds constrain the local ordering and orientation of molecules in solution, these local H-bond networks disband and reform on the picosecond time scale. This structural lability critically influences chemical and biological transformations.
News from the frontiers of brain science the brain-glue glia is useful.
Since just the majority of the cells in your brain is glia cells there might be somewhat useful information to know that the glia is not just about gluing the brain together, glia actually has a very important function to. But the fact that glia has been neglected for so many years are very impressive and might also tell us something about how fantastic selective.
If senses make sense then glia makes sense, since animals without glia lose their senses…
Neglected for centuries it might come as a stroke of lightening that 85% of the cells in your brain actually have a major function besides gluing the chemical synapses together, isn’t it fantastic? But the fact that glial cells have been largely neglected the last 100 years speaks with a very interesting voice about how selective and possibly even dysregulated the science of today can be. 2010 did the journal Science a special section on glia and the cells that is
Links about increasing the function of glia and what can happens when a low function increases with the glial growth stimulation factor. Science and Nuts at netvibes.
Some of the theories of Schizophrenia etiology mention the drug induced hallucinations as a raw-model for Schizophrenia but there is a problem with that – Persons with Schizophrenia doesn’t have these substances in their blood while hallucinating. Some drugs and some medicines might create states that remind of Schizophrenia: Ketamine and Phencyclidine (PCP) are the most mentioned. But the substances are not identified in the blood of the persons having the problem.
Here will in show the signs of lacking Oxygen and that there actually is a substance that can cause some of the symptoms and that persons with schizophrenia have it in their exhaled breath.
2
Lacking essentials as cause of Schizophrenia?
Probably, as much as 50% of the genes involved in the disease could be changed due to hypoxia. And seeing the BOLD results really tells me that they don’t get the oxygen needed. Can we really get a much stronger evidence of hypoxia?
The CO2 reactivity or the driving reaction to breath is also changed…
3
A substance that can give the symptoms is detected in the populations having the disease
We will show that there is in fact, a substance that by itself can create most of the symptomatology panorama and that this very substance also is detected in the individuals having disease. The substance is Carbon Sulfide or CS2. One of the most active metabolites are H2S (Hydrogen Sulfide) or more likely – H2S is the mother-substance and CS2 the metabolite.
ADHD is the same wherever you are! The signs are the same and so is the medication. But in different cultures this can express itself in different ways. But more and more realize that the ADHD phenomenon is global and it is not new at al. Science and Nuts are proud to present the Chinese ADHD information after the longest ADHD in Arabic on the web (i guess)
Short updates about the Science of ADHD and ADD
-Why does some persons grow out of hte symtoms of ADHD and some not?
-Well a good guess is that growth factors in the brain like BDNF and GDNF have a great role in this phenomenon. BDNF plays a very large role in depression and most of the known method of antidepressant actions affects the levels of BDNF. There are some data supporting that persons with low levels of BDNF and GDNF are more predestined to get in to abuse of alcohol or other drugs. On the other side increased levels of BDNF and GDNF decreases the craving of drugs and alcohol.
Some pictures about ADHD and ADD medications like Ritalin and Concerta on Flickr.
For reasons unknown to me, Concerta continues to be the main methylphenidate drug while it would in theory creates more adverse effects than the use of a pure d-methylphenidate formulation like the one used in Focalin. The theory behind that is the same as the theory and facts that makes Dexedrine (D-Amphetamine) more effective that the racemate amphetamine ( 50% L and 50% D-Amphetamine) or to mention an even more drastic example the difference between the L-Methamphetamine in Vicks inhalators and the D-Methamphetamine as in the worldwide epidemics that have shown that there really are drugs potent enough to shut down a crack house, might explain the difference practically.
Simply put it – the D version has the effect, the L version don’t. So why are they using the L-version at all? The formulation of newer brands like Adderall don’t make sense at all since they contain 25% of the L-Amphetamine which will increase the cardiovascular side effects and from a pharmacological point of view, but might do it from a short term commercial patentable perspective. Then we have the commercial benefits against the health of our child’s, and you are welcome. Why shall we not kill a company for that, it is just a company and how else can they learn?
Or is there really a reason to put L-Amphetamine in the D-amphetamine, as exemplified in Adderall? Well then maybe someone have the guts and the science to explain why. -So please come on! Don’t be shy, are there really any benefits for the children in receiving any central stimulating medication with the L-enantiomer, then where is the scientific proof of that? To boil up a smoke screen with some salts and some enantiomeric solutions like in Adderall has make it possible to sell the Amphetamine to a price 10 times higher than the old products and the molecule making the medicine effective are still the same as in 1950.
To put different salts on Amphetamine skeleton can have some logics in it but not to include the enatiomere with more cardiovascular side effects, or? To use D/L methylphenidate gives less effect with increased cardiovascular effect compared with pure D-Methylphenidate so why is it still used?
Girls tend to be overlooked when it comes to medical treatment of ADD cause a girl with ADD does not show the typical symptoms like a hyperactive young boy. Many blamed themselves instead and exhausted over the day falls into sleep frustrated. And the next morning the frustration is there again and says “dog mourning” like an dyslectic cacophony.
To not act out the frustration can often cause a feeling deeper sadness that easily transforms into something else: emotional disturbances, dysphoria and depression are more common with girls who have ADHD than with boys, if you ask me it is because the boys tend to act out the frustrations much more and then much easier can forget it. While girls with ADD to a higher degree blame themselves for their incapabilities, imagined or real. If the burden was to heavy to early, it might give harder but more brittle bones in a mental way and show up later as instabilities.
Addiction begins with ADD is not an old saying but in some 100 years it might be. A girl who’s does not feels confident with herself probably to a much higher degree than other have a need to be accepted fast and strong. That need can as the society looks today puts her in dangerous situations.
Physical exercise might be one way to increase the BDNFlevels and increase the relaxation afterwards, giving a greater potential to grow in.
From Ohm to Aum when the energy flow is the crown.
The engines of the the universal chemical energy source
ATP synthase is a protondriven molecular machine that works like a turbine to convert the energy stored in a proton gradient into chemical energy stored in the bond energy of ATP. This video shows how it works. F1Fo-ATP synthases produce the universal chemical energy source adenosine triphosphate (ATP) in most living organisms. They convert the energy stored in an electro-chemical gradient of protons or sodium ions into ATP and operate by a unique rotary mechanism. The ion gradient is utilized to generate torque of the machine’s rotor part against the stator part. This rotation induces conformational changes in the catalytic sites which are instrumental for ATP synthesis.
Schizophrenia and available energy – Exergy
Not just the ATP synthases are changed in Schizophrenia. Bellow the energy/metabolism related genes and proteins changed. They have been revealed as differentially expressed in transcriptome and proteome studies of Schizophrenia brain tissue
ATP5A1 ATP synthase, H+transporting, mitochondrial F1 complex, alpha subunit isoform bMiddleton et al.(2002) Altar et al.(2005)
Martins-de-Souza et al. (2008a)
Martins-de-Souza et al. (2009c)
ATP6V1A ATPase, H+ transporting, lysosomal 70kD, V1
subunit A, isoform 1. Altar et al.(2005)
Pennington et al. (2008)
Behan et al. (2008)
Martins-de-Souza et al. (2008a)
Martins-de-Souza et al. (2009a)
ALDOC Fructose bisphosphate aldolase C
Johnston-Wilson et al. (2000)
Prabakaran et al. (2004)
Clark et al. (2006)
Martins-de-Souza et al. (2009b)
Martins-de-Souza et al. (2008a)
Martins-de-Souza et al. (2009c)
CA2 Carbonic Anhydrase 2 Johnston-Wilson et al. (2000)
Beasley et al. (2006)
Martins-de-Souza et al. (2009b)
CKB Creatine kinase, B chain Prabakaran et al. (2004)
Clark et al. (2006)
Beasley et al. (2006)
Sivagnanasundaram et al. (2007)
Behan et al. (2008)
Martins-de-Souza et al. (2009a)
Martins-de-Souza et al. (2009c)
ENO2 Gamma enolase (2-phospho-D-glycerate hydro-lyase)
Prabakaran et al. (2004)
Sivagnanasundaram et al. (2007)
Pennington et al. (2008)
Martins-de-Souza et al. (2009c)
ACO2 Aconitate hydratase, mitochondrial precursor (Aconitase)
Prabakaran et al. (2004)
Beasley et al. (2006)
Martins-de-Souza et al. (2008b)
Martins-de-Souza et al. (2009c)
HK1 Hexokinase brain form Prabakaran et al. (2004)
Martins-de-Souza et al. (2009b)
Martins-de-Souza et al. (2009a)
GAPDH Glyceraldehyde-3-Phosphate dehydrogenase
Prabakaran et al. (2004)
Martins-de-Souza et al. (2009c)
PGAM1 Phosphoglycerate mutase 1 Prabakaran et al. (2004)
Martins-de-Souza et al. (2009c)
TPI1 Triosephosphate isomerase Prabakaran et al. (2004)
Martins-de-Souza et al. (2009c)
Since the ADHD medication to some seems suspect and strange, we will continue with the analysis of the Methylphenidate molecular whereabouts, we once more consult the electron microscope to see I the backlight beauty reveal any crystalline secrets to the trained eye or to the complete novice. Here you can find the first two Concerta videos. Are there any deeper conspirational themes in the molecular structures of centrally acting medications against the symptoms of ADD and ADHD? Or is that just an invention by the constipated minds who want to sell their version of why some kids are getting dramatically better by this and medication like this?
In that case they maybe want you to buy it on behalf of the kid’s health without offering something better. Or do they have anything better to offer? Then where are the proofs of that?
Is it crystalline clear or is there any suspect pattern?
The last video is from Dr Russell Barkley who talks about ADHD: To medicate or not. And what might happens if you do ant don’t.
The history of ADHD ADHD is not new at all; the Scottish physician Alexander Cricthon described the symptoms in already 1798 before becoming the personal physician to the Tsar Alexander. Coming up later the history of ADHD medicine
Semen Quality – Paternal age The age of the Father has proved to be another of the factors affecting the likelihood of having children who later develop schizophrenia. A copy of a copy that later on will be copied and so on this is the story about the sperm. And the duplicating errors will probably […]
We have transfered the ADHD History to the specialized site: The History of ADHD The ADHD History starts back in 1798 with the first known medical recording of the symptoms by Alexander Crichton. The next part is from 1902 by Sir George F Still. Pages The History of ADHD part 1: 1798 Alexander Crichton […]
Water can Dance – And really it does. Quantum theory have long described the importance of the hydrogen binding network but the knowledge have been purely theoretical. Now we can see that water can switch dance partner About once every six picoseconds. And that will be around 160 billion times a second. If the water […]
News from the frontiers of brain science the brain-glue glia is useful. Since just the majority of the cells in your brain is glia cells there might be somewhat useful information to know that the glia is not just about gluing the brain together, glia actually has a very important function to. But the fact […]
1 To little or to much of a substance? Some of the theories of Schizophrenia etiology mention the drug induced hallucinations as a raw-model for Schizophrenia but there is a problem with that – Persons with Schizophrenia doesn’t have these substances in their blood while hallucinating. Some drugs and some medicines might create states that remind […]
Continued from the fastest way to a smaller brain I Question about Haloperidol The main effects of Haldol is probably the blockade of the Dopamine-2 receptor (D2) Haldol is pretty effective in doing that and there is no daught about that, but in the long run Haldol up-regulates the D2 receptors (2). I can hardly […]
If you don’t know how – then you are really stupid Many drugs have together with alcohol been said to destroy brain cells, or decrease the density. That could be true in some cases, but the fastest way to lose brain tissue and cells are not a narcotic drug, it is not alcohol, nor is […]
الحالة في تلك الآونة، على سبيل المثال اختلال بسيط في وظائف المخ ) MBD (، ومتلازمة فرط الحركة واضطراب قلة الانتباه وحالة الإعاقة الإدراكية الحركية ) MPH ( ويطلق عليها في الوقت الحالي اضطراب فرط الحركة وقلة الانتباه ADHD( (. يعكس إطلاق العديد من الأسماء على نفس الحالة على مدار السنين حقيقة وجود وجهات نظر […] […]
Flickr ADHD – ADD For reasons unknown to me, Concerta continues to be the main methylphenidate drug while it would in theory creates more adverse effects than the use of a pure d-methylphenidate formulation like the one used in Focalin. The theory behind that is the same as the theory and facts that makes Dexedrine […]
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