Glial Cell Line-Derived Neurotrophic Factor

All posts tagged Glial Cell Line-Derived Neurotrophic Factor

Brain glue can be good to – Glia GDNF

Posted by gdnf on April 21, 2011
Posted in: Neuroscience, Science. Tagged: , , , .

News from the frontiers of brain science the brain-glue glia is useful.

Since just the majority of the cells in your brain is glia cells there might be somewhat useful information to know that the glia is not just about gluing the brain together, glia actually has a very important function to. But the fact that glia has been neglected for so many years are very impressive and might also tell us something about how fantastic selective.

If senses make sense then glia makes sense, since animals without glia lose their senses…

Neglected for centuries it might come as a stroke of lightening that 85% of the cells in your brain actually have a major function besides gluing the chemical synapses together, isn’t it fantastic? But the fact that glial cells have been largely neglected the last 100 years speaks with a very interesting voice about how selective and possibly even dysregulated the science of today can be. 2010 did the journal Science a special section on glia and the cells that is

What is GDNF and what can it do?

Read the fantastic page from Science and Nuts about the glial derived neurotropic factor (GDNF) and how GDNF.

Links about increasing the function of glia and what can happens when a low function increases with the glial growth stimulation factor. Science and Nuts at netvibes.

Ibogaine GDNF and Alcohol Addiction

Posted by gdnf on February 19, 2010
Posted in: Ibogaine. Tagged: , , , , , , , , , .

GDNF Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption

Ibogaine-GDNF & related at Scribd.

In this study, they first characterized the actions of ibogaine on ethanol self-administration in rodents. Ibogaine decreased ethanol intake by rats in 2 bottle choice and operant self-administration paradigms. Ibogaine also reduced operant self administration of ethanol in a relapse model. Next, they identified a molecular mechanism that mediates the desirable activities of ibogaine on ethanol intake.

 

BIG News in Alcohol Addiction: New Findings on Growth
Factor Pathways BDNF, Insulin, and GDNF
In recent years, it has become clear that growth factors are not only critical for the development of the central nervous system (CNS) but may also be important contributors to other neuronal functions in the adult brain.

A decrease in the function of a particular growth factor increases the behavioral effect of alcohol. Increases in GDNF and BDNF are reported to decrease alcohol intake, whereas decreases in BDNF are associated with increased alcohol intake. In addition, decreases in insulin signaling lead to increases in the intoxicating effects of alcohol. Hence, these 3 factors may be important nervous system defenses against pharmacological effects of alcohol on behavior.