Girls tend to be overlooked when it comes to medical treatment of ADD cause a girl with ADD does not show the typical symptoms like a hyperactive young boy. Many blamed themselves instead and exhausted over the day falls into sleep frustrated. And the next morning the frustration is there again and says “dog mourning” like an dyslectic cacophony.
To not act out the frustration can often cause a feeling deeper sadness that easily transforms into something else: emotional disturbances, dysphoria and depression are more common with girls who have ADHD than with boys, if you ask me it is because the boys tend to act out the frustrations much more and then much easier can forget it. While girls with ADD to a higher degree blame themselves for their incapabilities, imagined or real. If the burden was to heavy to early, it might give harder but more brittle bones in a mental way and show up later as instabilities.
Addiction begins with ADD is not an old saying but in some 100 years it might be. A girl who’s does not feels confident with herself probably to a much higher degree than other have a need to be accepted fast and strong. That need can as the society looks today puts her in dangerous situations.
Physical exercise might be one way to increase the BDNFlevels and increase the relaxation afterwards, giving a greater potential to grow in.
In recent years, it has become clear that growth factors are not only critical for the development of CNS but may also be important contributors to other neuronal functions in the adult brain. A decrease in the function of a BDNF and GDNF increases the behavioural effect of alcohol. Increases in GDNF and BDNF are reported to decrease alcohol intake, whereas decreases in BDNF are associated with increased alcohol intake. In addition, decreases in insulin signaling lead to increases in the intoxicating effects of alcohol. Hence, these factors may be important CNS-defense against pharmacological effects of alcohol on behaviour.
BDNF and ADHD
There are many indirect connections between ADHD and neurotrophic factors like BDNF. Since exercise alters the BDNF levels it is easy to presume that the hyperactivity originating from a natural instinct to balance the trial and error with compression of time – Anything but NOW! The medications against core symptoms like the inability too keep sustained attention often seems to raise the BDNF levels in low doses, but in high doses known to do the opposite.
How “The Lead motive” can alter the function of the prefrontal cortex is just one of the stressor effects that can result in states that have the characteristics of ADHD. Stress signalling pathways that impair prefrontal cortex structure and function.
Deeper look into the hypothesis that BDNF is involved in the pathogenesis of ADHD.
BDNF and stress
As we now know to high amount of stress for to long can cause lover the levels of BDNF, and hence also come with an reasonable explanation stress especially early stress can change so much in life.
BDNF, Affective Disorders, anxiety and memory
Listen to Dr. Francis Lee who have combined mouse and human studies to shed light on the mechanisms by which a defect in a the BDNF gene can lead to anxiety symptoms in mental disorders.
More about BDNF
BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells.
Understanding the etiology and pathogenesis schizophrenia and depression is a major challenge facing psychiatry. One hypothesis is that these disorders are secondary to a malfunction of neurotrophic factors. Inappropriate neurotrophic support during brain development could lead to structural disorganisation in which neuronal networks are established in a nonoptimal manner.
The future of BDNF
An upregulation of the BDNF feedback loop is what some Ampakines promise, almost like the change in GDNF feedback loop by ibogaine. The effects are very interesting when the actions of the substance is there when there is no substance there, that means that we have an true cognitive enchanter, not just a short term effector.
BDNF or Brain-derived neurotrophic factor makes some nerve cells get into the groove and orchestration of new connections.
BDNF and the evolution of you (me)
BDNF can be altered in many ways like you and your health. Exercise for example raises the levels of BDNF and so does a diet low in carbohydrates and fasting.
BDNF and Depression
Almost every known method of antidepressant effects also raises the functional levels of BDNF. On the other hand a decrease in BDNF can result in shrinking density in hippocampus and depression. A prolonged exposure to stresshormones like corticosterone downregulates BDNF.
More recently, impairment in the functioning of pan75 neurotrophin receptor has been reported in suicide brain specimens. pan75 neurotrophin receptor is a low-affinity neurotrophin receptor that, when expressed in conjunction with low availability of neurotropins/Trks, induces apoptosis. Overall, these studies suggest the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. This review focuses on the critical evidence demonstrating the involvement of BDNF in depression and suicide.
Results: A failure of hippocampal activation and 16% smaller volume of the hippocampus were seen in women with abuse and PTSD compared to women with abuse without PTSD. Women with abuse and PTSD had a 19% smaller hippocampal volume relative to women without abuse or PTSD.
Conclusions: These results are consistent with deficits in hippocampal function and structure in abuse-related PTSD.
Downregulation of BDNF mRNA in the Hippocampal Dentate Gyrus after Re-exposure to Cues Previously Associated with Footshock
This study examined the effects of footshock stress and re-exposure to cues previously associated with footshock on expression of brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus of male rats.
The data suggest that psychological, as well as unconditioned physical stress, can decrease hippocampal BDNF mRNA. Possible implications for stress-related and other neuropsychiatric disorders associated with deficits in hippocampal function and volume, such as depression, post-traumatic stress disorder, and Alzheimer’s Disease, are discussed.
Science and Nuts 