Science and Nuts

From Part 1

part II the CAC-hålet theory

The etiology of Schizophrenia could be linked to endogenous Carbon disulfide CS2 production. The manufacture and exposure to endogenous CS2, could probably act in months after months before showing some of the symptoms of high CS2 exposure (Hallucinations, Psychosis and personality changes)

Suggestions

To ensure a proper analysis of earlier undetectable biomarkers one might consider gas-analysis from skin and breath as an biomarker and emission source, since the CS2 otherwise could leave undetected through the biggest organ –  the skin. I propose analysis of total air content in a closed chamber with subjects naked to avoid contamination with techniques for gas detection (59), (60) to reveal the biometrics of human endogenous CS2 production. Which has not been done to my knowledge.

By practising these suggestions it might be easier to understand and prevent the disease by detecting the prodromal and active  systems conditions besides the genetic vulnerability and map out what role CS2 play in the etiology of Schizophrenia.

References:

(1)
Wien Klin Wochenschr. 1958 Jun 13;70(24):445-6.
[Schizophreniform reactions in chronic carbon disulfide poisoning.]
[Article in German]
Petran V
(2)
Clin Pathol 1993;46:861-864
Increased pentane and carbon disulfide in the
breath of patients with schizophrenia
M Phillips, M Sabas, J Greenberg
(3)
Respiration. 1987;52(1):34-41.Links
Respiratory sensitivity to carbon dioxide in schizophrenia.
Verma R, Dewan M, Ashutosh K.
(4)
Acta Psychiatr Scand. 1990 Jun;81(6):497-506.
Cerebral blood flow responses to inhaled carbon dioxide in schizophrenia.
Mathew RJ, Wilson WH.
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
(5)
Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1473-95.
Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation.
(6)
Adv Exp Med Biol. 2006;588:65-73
Control of cerebral blood flow during sleep and the effects of hypoxia.
Corfield DR, Meadows GE
(7)
J Korean Med Sci. 1998 Dec;13(6):645-51. Cerebral vasoreactivity by transcranial Doppler in carbon disulfide poisoning cases in Korea. Lee E, Kim MH.
(8)
Br J Anaesth. 2008 Nov;101(5):673-9. Epub 2008 Sep 12.
Carbon dioxide negatively modulates N-methyl-D-aspartate receptors.
Brosnan RJ, Pham TL.
(9)
1994: Kumar M; Lu W P; Ragsdale S W
Binding of carbon disulfide to the site of acetyl-CoA synthesis by the nickel-iron-sulfur protein, carbon monoxide dehydrogenase, from Clostridium thermoaceticum.
Biochemistry 1994;33(32):9769-77.
(10)
Chin Med J (Engl). 2008 Dec 20;121(24):2553-6.
Effects of carbon disulfide on the expression and activity of nitric oxide synthase in rat hippocampus.
Guo XM, Tang RH, Qin XY,Yang J, Chen GY.
(11)
Yang KS, Choi HR, Kim JJ, et al. Study of carbon disulfide intoxication.
Seoul: Korean Ministry of Labor Press, 1999
(12)
Lee E, Kim MH. Cerebral vasoreactivity by transcranial Doppler in carbon disulfide poisoning cases in Korea. J Korean
Med Sci 1998;13:645-651
(13)
J Korean Med Sci. 1998 Dec;13(6):645-51. Cerebral vasoreactivity by transcranial Doppler in carbon disulfide poisoning cases in Korea. Lee E, Kim MH.
(14)
Biochem. J. (1980) 188, 107-1 12 107
The Effects of Carbon Disulphide on Rat Liver Microsomal Mixed-Function
Oxidases, in vivo and in vitro
Maria J. OBREBSKA,* Peter KENTISH and Dennis V. PARKE
(15)
Journal of Ncurochcmistru. 1971, Vol. 18, pp. 177 to 182. Pergamon Press.
Oxidation and phosphorylation processes in brain mithochondria of rats exposed to carbon disulfide.
S. Tarkowski Hanna Sobczak
(16)
Lefaux, R. 1968. Carbon disulphide. Pp. 117-119 in Practical Toxicology of Plastics. Cleveland, OH: Chemical Rubber Company
(17)
Gorny, R., Carbon disulfide-induced vitamin 96 deficiency in rats fed diets with different vitamin B6 contents, Bromarol. Chem. Toksykol., 13(3), 299, 1980.
(18)
Washuettl, J., Winker, N., and Steiner, I.,The effects of carbon disulfide on the vitamin BI content in the serum of exposed workers, Munch. Med. Wochenschr., 121(24), 819, 1979.
(19)
165. Miyagawa, K., Carbon disulfide poisoning – Effects of L-methionine and L-methionine
combined with vitamin B12 on carbon disulfide poisoning, Shikoku Acra Med., 6(3), I, 1955.
(20)
Wronska-Nofer,. T., Nofer, J., and Stanislaw, T., Disorders in excretion of niacin metabolites in carbon disulfide-poisoned animals, Med. Pr., 16, 77, 1965.
(21)
Wronska-Nofer, T., The influence of low doses of nicotinic acid upon the development
of lipid disturbances in rats chronically exposed to carbon disulphide, hi. Arch. Arbeitsmed., 29(4), 285, 1972.
(22)
Knobloch, K., Effect of nicotinamide on excitability of the vestibular nerve and some motor nerves in chronic carbon disulfide poisoning in guinea pigs, Med. Pr., 12, 355, 1961.
(23)
Kuljak, S. and Stern, P., Protective effect of glutathione and xanthinol nicotinate against carbon disulfide poisoning in the mouse, Arh. Hig. Rada Toksikol., 22(2), 137, 1971
(24)
Paine, A. J., Williams, L., and Legg, R. F., Apparent maintenance of cytochrome P450 by
nicotinamides in primary cultures of rat hepatocytes, Life Sci., 24, 2185, 1979.
(25)
Silvestroni, A. and Rimiani, R., Microcirculation in chronic experimental intoxication with carbon disulfide. Effects of nicotinic acid, Folia Med., 53, 1, 1970.
(26)
McKenna, M. J. and DiStefano, V., Carbon disulfide. I. The metabolism of inhaled carbon disulfide in the rat, J. Pharmacol. Exp. Ther., 202(2), 245, 1977
Reaction of carbon disulfide with blood in vitro, Prac. Lek., 6, 11, 1954.
(27)
Brieger, H., Carbon disulfide in the living organism-retention, biotransformation and
pathophysiologic effects, in Toxicology of Carbon Disulfide, Brieger, H., Ed., Excerpta Medica Foundation,
Amsterdam, 27, 1967.
(28)
Gadaskina, I. D. and Andreeva, N. B., Biochemical shifts occurring in the organism
following carbon disulfide poisoning (free SH groups and blood ceruloplasmin; copper and zinc metabolism), Gig. Tr. Prof. Zabol.. 13, 28, 1969.
(29)
Kotas, P., Obrusnik, I., Lukas, E., and Krivanek, M., Determination of zinc and copper in the
periphera nerves of rats with carbon disulfide-induced neuropathy, J. Radioanal. Chem., 19(2), 263, 1974.

(30)
(Scheel, 1967). ISBN 92 4 154070 2, World Health Organization 1979
COHEN AE, SCHEEL LD, KOPP JF, STOCKELL FR, Jr, KEENAN RG, MOUNTAIN JT, PAULUS HJ.
Biochemical mechanisms in chronic carbon disulfide poisoning. Am Ind Hyg Assoc J. 1959
Aug;20(4):303–323.
(31)
Wilmarth KR, Froines JR (November 1992). “In vitro and in vivo inhibition of lysyl oxidase by aminopropionitriles”. J Toxicol Environ Health 37 (3): 411–23. PMID 1359158
(32)
Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol.
2001; 70: 1–32.
(33)
Chem Res Toxicol. 1998 May;(5):544-9.
Carbon disulfide and N,N-diethyldithiocarbamate generate thiourea cross-links on erythrocyte spectrin in vivo.
Erve JC, Amarnath V, Graham DG, Sills RC, Morgan AL, Valentine WM.
(34)
Volume 272, Number 51, Issue of December 19, 1997 pp. 32370-32377
Irreversible Inhibition of Lysyl Oxidase by Homocysteine Thiolactone and Its Selenium and Oxygen Analogues Implications for Homocystinuria
(35)
Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22:1409-1414
Low Density Lipoproteins Downregulate Lysyl Oxidase in Vascular Endothelial Cells and the Arterial Wall Cristina Rodríguez ; Berta Raposo ; José Martínez-González ; Laura Casaní ; and Lina Badimon
(36)
Madlo, Z. and Soucek, B., Absorption, metabolism, and action of carbon disulfide in the organism. VII. Inhibition of serum cholinesterase by carbon disulfide, Prac. Lek., 6, 312, 1953
Soucek, B. and Madlo, Z., Absorption metabolism, and action of carbon disulfide in the organism. VIII.
(37)
Acta Neuropathol. 1984;63(3):255-63.Links
Ultrastructure of carbon disulphie neuropathy.
Jirmanová I, Lukás E.
(38)
Ca2+ Calmodulin levels was increased in cerebral cortex, hippocampus and spinal cord. Volume 179, Issues 2-3, 15 May 2009, Pages 110-117 Changes of lipid peroxidation in carbon disulfide-treated rat nerve tissues and serum Da-Qing Suna, b Ai-Wu Lic, , Ju Lid, Dian-Guo Lib, Yi-Xin Lib, Hao-Fengb and
Ming-Zhi Gongb, Chemico-Biological Interactions.
(39).
Davidson M, Feinleib M. Carbon disulfide poisoning: A review.
Am Heart J 1972;83:100-114
(40).
Lee KB, Byoun HJ, Choi TS, Kim SS, Cho WY, Kim HK.
Clinical manifestation of chronic carbon disulfide intoxication.
Korean J Int Med 1990;39:245-251
(41).
Choi JW, Jang SH. A review of the carbon disulfide poisoning
experience in Korea. Korean J Occup Med 1991;3:11-20
(42).
Yang KS, Choi HR, Kim JJ, et al. Study of carbon disulfide intoxication.
Seoul: Korean Ministry of Labor Press, 1999
(43)
Aaserud O, Gierstad L, Nakstad P, et al. Neurological examination,
computerized tomography, cerebral blood flow and neurophysiological
examination in workers with long-term exposure
to carbon disulfide. Toxicology 1988;49:277-28
(44)
Aaserud O, Hommeren OJ, Tvedt B, et al. Carbon disulfide exposure
and neurotoxic sequelae among viscose rayon workers.
Am J Ind Med 1990;18:23-37
(45)
Sugimura K, Kabashima K, Tatetsu S. Computerized tomography
in chronic carbon disulfide poisoning. No to Shinkei 1979;
31:1245-1253
(46)
Huang CC, Chu CC, Chen RS, et al. Chronic carbon disulfide
encephalopathy. Eur Neurol 1996;36:364-368
(47)
Peters HA, Levine RL, Matthews CGM et al. Extrapyramidal
and other neurologic manifestations associated with carbon
disulfide fumigant exposure. Arch Neurol 1988;45:537-540
(48)
Ca2+ Calmodulin levels was increased in cerebral cortex, hippocampus and spinal cord. Volume 179, Issues 2-3, 15 May 2009, Pages 110-117 Changes of lipid peroxidation in carbon disulfide-treated rat nerve tissues and serum Da-Qing Suna, b Ai-Wu Lic, , Ju Lid, Dian-Guo Lib, Yi-Xin Lib, Hao-Fengb and
Ming-Zhi Gongb, Chemico-Biological Interactions.
(49)
Alterations of microtubule and microfilament expression in spinal cord of carbon disulfide intoxicated rats. Chinese journal of industrial hygiene and occupational diseases. Original title: Zhonghua lao dong wei sheng zhi ye bing za zhi Zhonghua laodong weisheng zhiyebing zazhi. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Mar;25(3):148-51 Pan GB, Song FY, Zhao XL, Yu LH, Zhou GZ, Xie KQ.
(50)
Toxicological Sciences 94(2), 240–255. Richard M. LoPachin. David S. Barber
doi:10.1093/toxsci/k?066 Advance Access publication July 31, 2006
(51)
Chin Med J (Engl). 2008 Dec 20;121(24):2553-6.
Effects of carbon disulfide on the expression and activity of nitric oxide synthase in rat hippocampus.
Guo XM, Tang RH, Qin XY, Yang J, Chen GY.
(52)
Schizophr Res. 2000 Feb 14;41(3):405-15
Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?
Catts VS, Catts SV.
Schizophrenia Research Unit, South Western Sydney Area Health Service, Liverpool Hospital, Liverpool, NSW, Australia.
(53)
Int J Hyg Environ Health. 2007 Jan;210(1):69-77. Epub 2006 Sep 1.
Use of genotypic selection to detect P53 codon 273 CGT>CTT transversion: application to an
occupationally exposed population.
Carton T, Tan XD, Hartemann P, Joyeux M.
(54)
Forensic Sci Int. 2005 Oct 29;153(2-3):147-55. Epub 2004 Nov 25.
A study of volatile organic compounds evolved from the decaying human body.
Statheropoulos M, Spiliopoulou C, Agapiou A.
School of Chemical Engineering, National Technical University of Athens (NTUA)
(55)
(Purdon et al., 2002; Purdon and Rapoport, 2007).
(56)
Bartonicek V. The distribution of carbon disulfide in whole blood, the brain and the suprarenal gland over a given period in parenteral administration in white mice. Prac Lek 1957; 9:28-30.
(57)
The modification of genetic expression after CS2 exposure have been shown in humans with p53. Chem Biol Interact. 2009 May 15;179(2-3):110-7. Epub 2008 Nov 25.
Changes of lipid peroxidation in carbon disulfide-treated rat nerve tissues and serum.
Sun DQ, Li AW, Li J, Li DG, Li YX, Hao-Feng, Gong MZ.
Shandong University, Jinan, Shandong, China.
(58)
Schizophrenia Research Volume 62, Issue 3, 1 August 2003.
The niacin skin flush test in schizophrenia- a combined a quantitative dose–response study
(59)
MCCANN Patrick, NAMJOU Khosrow, ROLLER Chad, MCMILLEN Gina, KAMAT Pratyuma. IV-VI Semiconductor Lasers for Gas Phase Biomarker Detection
Proceedings of SPIE, the International Society for Optical Engineering ISSN 0277-786X
(60)
Mater. Res. Soc. Symp. Proc. Vol. 891 © 2006 Materials Research Society
Patrick J. McCann1 and Yurii Selivanov2 1 School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019 2 P. N. Lebedev Physical Institute, Russian Academy of Sciences, Leninskii Pr. 53, 119991, Moscow, Russia
(61)
Br J Anaesth. 2008 Nov;101(5):673-9. Epub 2008 Sep 12.
Carbon dioxide negatively modulates N-methyl-D-aspartate receptors. Brosnan RJ, Pham TL.
(62)
Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1473-95.
Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation.
(63)
Adv Exp Med Biol. 2006;588:65-73
Control of cerebral blood flow during sleep and the effects of hypoxia.
Corfield DR, Meadows GE
(64)
Activity of glutamate decarboxylase in the brain of rats exposed to carbon disulfide
International Archives of Occupational and Environmental Health Volume 33, Number 1 / March, 1974
Stanislstrokaw Tarkowski
(65)
Tarkowski S, Cremer JE. 1972. Metabolism of glucose and free amino acids in brain, studied with C-labelled glucose and butyrate in rats intoxicated with carbon disulfide. J Neurochem
19:2631-2640.
(66)
The Journal of Neuroscience, 1999, 19:RC16:1-9
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