Some facts about the incidence of Schizophrenia and it’s variability

-There seems to be a higher incidence associated with urbanity, living the first 2 years in urban areas seems  have an effect on incidence

-There seems to be a higher incidence associated with migration

-Greater lifetime risk in males and earlier onset in males

-Higher prevalence among lower socio-economic classes

-Schizophrenia is highly heritable and genetic factors seems to

-Schizophrenia is highly heritable and genetic factors contribute to approximately 80% of the liability for the illness.

-Several environmental factors of small effect, winter/spring birth, prenatal infection- (especially cytomegalovirus infection) and famine, obstetric and perinatal complications, social stress, older paternal age, etc.) are associated with an increased risk of developing schizophrenia

The global distribution of Schizophrenia according to WHO 2002

Pictures from wikipedia.

The Etiology of Schizophrenia – The Hypo-Thesis of Cognition – (Pdf) part 1 about Endogenous Carbon Disulfide CS2 and its Consequences.

After the next step of the CAC-Hålet theory dealing with the metabolites: H2S and COS, we will see if it is possible to integrate the epidemiological findings above into a more global picture of the prevalence, but maybe that is to big Utopia. Anyway the inhibition of Carbonic Anhydrase Catalysis – CAC by the metabolites show an interesting picture: how the Co2 reactivity gets slower.