painkillers

All posts tagged painkillers

Narcotic Drugs and neurotrophic substances

Posted by gdnf on July 19, 2010
Posted in: Addiction, Ibogaine. Tagged: , , , , , , , , .

Can brain grow up and heal from a destructive addiction to narcotic drugs? Yes, probably, some ways seems hopeful but yet dangerous. Ibogaine up-regulates the feedbackloop of GDNF (Glia Derived Neurotrophic Factor) in the brain and it stays up-regulated for at least some months and this seems to be the mechanisms of the antiaddictive effects of Ibogaine. But Ibogaine is also associated with some fatalities when taken in a non-medical setting.

David Graham Scott has been addicted to drugs for nearly 20 years, or as he puts it, “four on heroin and the rest on methadone.” You will stay alive but can you really feel the life? David decides to try the potentially dangerous substance Ibogaine.

Filmed by Scott himself over a five-year period, this emotionally charged documentary follows his double life as a heroin abuser and filmmaker, his pattern of deceit with his family, his battle to conquer methadone, and the fight to finally beat his addiction. His desperation to overcome drugs causes him to risk all on an unauthorized, controversial, and potentially lethal method that promises to limit withdrawal symptoms to one day—but sends the patient on a soul-searching, gut-wrenching 36-hour detox. Some content may be objectionable, and some language may be offensive. But not more offensive than the reality it comes from.

Broadcast by BBC 2004 (One Life). Gold Medal winner New York Film Festivals 2005.

Dr. Deborah Mash speaks about ibogaine and addiction. A short Clip from: BBC’s Horizon Special Psychedelic Experience. Dr Deborah Mash comments Voices from the underground about a mystic substance that is supposed to have more or less magic effects on hardcore addicts. Is it true or just another nut from the crackheads? You tell me.

 

 

What is GDNF and what can it do?

Posted by gdnf on April 24, 2010
Posted in: Addiction, Ibogaine. Tagged: , , , , , , , , , , .

The name of the blog  is inspired by two neurotrophic factors. The first one: GDNF or Glial cell-derived neurotrophic factor is a neurotrophic factor that play key roles in the control of growth and differentiation of the dopamin neuron, and as an potent survival factor for dopaminergic, noradrenergic and spinal motor neurons. In Parkinson’s  disease the results have been mixed, but some results are fantastic.

GDNF and the Amgen trial.


Anti-Addicive effect of GDNF

The antiaddictive effects of Ibogaine is mediated by GDNF in the ventral tegmental area. Researchers found that GDNF infusion very rapidly and dose-dependently reduced rat ethanol, self-administration:

Importantly, we demonstrate that GDNF infused into the VTA alters rats’ responses in a model of relapse. Specifically, GDNF application blocked reacquisition of ethanol self-administration after extinction. Together, these results suggest that GDNF, via activation of the MAPK pathway, is a is a fast-acting selective agent to reduce the motivation to consume and seek alcohol. fast-acting selective agent to reduce the motivation to consume and seek alcohol. (1)

we showed that the sustaineda ctions of ibogaine are mediated via an autoregulatory positive feedback loop in which GDNF triggers its own expression.

    Ibogaine have been used to cure addictions from:Heroin, Morphine, Methadone and Painkillers.

The Root of Hope – Ibogaine – Begreppseken

Could the answer to America’s drug problem lie in an African root? Supporters say Ibogaine can treat Oxycontin, Vicodin, alcohol and heroin addiction.

(1) GDNF is a fast-acting potent inhibitor of alcohol
consumption and relapse
Sebastien Carnicella, Viktor Kharazia, Jerome Jeanblanc, Patricia H. Janak, and Dorit Ron
The Ernest Gallo Research Center and †Department of Neurology, University of California at San Francisco, Emeryville, CA 94608
Edited by Hans Thoenen, Max Planck Institute of Neurobiology, Martinsried.

 

The importance of Drugs

Posted by gdnf on April 11, 2010
Posted in: Ibogaine. Tagged: , , , , , , , , , , , .

Maybe impressions from drugs and persons with visions have created al religions as we know them, have inspired countless artworks, musical escapades smash hits and countless tragic deaths. So to deny the importance of drugs in society seems to just create a state of denial.

But as drugs can inspire and sometimes help, we also have to realize something we can’t see, the dead ones and the addicts who take their last breath in this very moments. Those who standing beside the 99-years old woman who says -i have been smoking cigarettes al my life and drinking whiskey to. But how often can we really see the choir of persons standing beside them without any body at al? How often do we listen to the message from the true witnesses? They paid al they had and now they don’t even have a voice, shall we really listen to them?

The science of Antiaddiction

With that in mind, we could realize that drugs have it’s ups and downs and that there is an shure hell getting caught in severe addiction. Here you can find more scientific information about ibogaine.

Le origins du Monde, Ibogaine video at clipmoon with Deborah Mash.

  • 06:07 Ibogaine Root of hope

    Could the answer to America’s drug problem lie in an African root? Supporters say Ibogaine can treat Oxycontin, Vicodin, alcohol and heroin addiction. Some former drug addicts swear by it. Others warn it’s too dangerous. In this Special Assignment investigation, CBS 2’s Laura Diaz explores the “Root Of Hope”.

  • CAC News on Ibogaine Treatment 20 Feb, 2004 – BAY AREA (KRON 4) – Drug addiction has been the plague of modern America. But that could now change forever. What started as a rumor may now actually be an incredible breakthrough in the battle against addictions.

  • CBS-nyheterna rapporterar om iboagin 04:57 CBS-news

  • Ibogaine 10:22 Ibogaine

    The very last hope..

    Is there a life with heroin and methadone or is it just like Howard Lotsof said an emulation of Death?

The Fathers of the Ectacy Generation STOP’s taking Drugs?

Posted by gdnf on February 14, 2010
Posted in: Addiction, Ibogaine, Neuroscience. Tagged: , , , , , , , , , , .

What is happening to our world, a junkie is not a junkie for lite anymore, or?

Ibogaine Documentary: The real cure for Addiction?

The former bass player in Happy Mondays Paul Ryder investigate the jungle of rumours about Ibogaine – Is it really working? Is there a conspiracy? What about the claims?

A short teaser.. starting on the black and white squares in Stockholm Sweden, Sergel’s Torg, looking in the the drug trading taking place.

The girl passing by the camera once had a megahit:

Psychological poems fun funky fresh

Ain`t down with horse ain`t down with smack
I`m a flygirl packed with rap
When I grab the microphone
You better move your butt
Homeboys in the house show me what you`ve got
I`m Leila K on the M.I.C.
Come on come with me to the place to be

About Ibogaine pharmacology.

Paul – the abstinence is Comming….. s t r o n g e r …
… Starting getting shivers..
—
Paul in bed – just taken Ibogaine
Paul in bed just after taken some ibogaine. Paul Ryder who set the world on fire with brother Shaun in The Happy Mondays is getting clear from the drugs
—
just out of bed
—

Paul after ibogaine treatment – getting better and better & moore awake

Ibogaine can also cause problems. Instead of severe Heroin withdrawal this individual now is very worried about having a bad hairday. 😉 No sicncearly Ibogaine is a very powerful substance that never should be taken to likely it is powerful an can be very dangerous it handled with knowledge and care.
—
The science of Ibogaine:

Ibogaine GDNF and Alcohol Addiction

GDNF collection & Ibogain Scientific Resources

Video about Ibogaine ibogaine by Youtube begreppseken.