Heroin

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Narcotic Drugs and neurotrophic substances

Posted by gdnf on July 19, 2010
Posted in: Addiction, Ibogaine. Tagged: , , , , , , , , .

Can brain grow up and heal from a destructive addiction to narcotic drugs? Yes, probably, some ways seems hopeful but yet dangerous. Ibogaine up-regulates the feedbackloop of GDNF (Glia Derived Neurotrophic Factor) in the brain and it stays up-regulated for at least some months and this seems to be the mechanisms of the antiaddictive effects of Ibogaine. But Ibogaine is also associated with some fatalities when taken in a non-medical setting.

David Graham Scott has been addicted to drugs for nearly 20 years, or as he puts it, “four on heroin and the rest on methadone.” You will stay alive but can you really feel the life? David decides to try the potentially dangerous substance Ibogaine.

Filmed by Scott himself over a five-year period, this emotionally charged documentary follows his double life as a heroin abuser and filmmaker, his pattern of deceit with his family, his battle to conquer methadone, and the fight to finally beat his addiction. His desperation to overcome drugs causes him to risk all on an unauthorized, controversial, and potentially lethal method that promises to limit withdrawal symptoms to one day—but sends the patient on a soul-searching, gut-wrenching 36-hour detox. Some content may be objectionable, and some language may be offensive. But not more offensive than the reality it comes from.

Broadcast by BBC 2004 (One Life). Gold Medal winner New York Film Festivals 2005.

Dr. Deborah Mash speaks about ibogaine and addiction. A short Clip from: BBC’s Horizon Special Psychedelic Experience. Dr Deborah Mash comments Voices from the underground about a mystic substance that is supposed to have more or less magic effects on hardcore addicts. Is it true or just another nut from the crackheads? You tell me.

 

 

What is GDNF and what can it do?

Posted by gdnf on April 24, 2010
Posted in: Addiction, Ibogaine. Tagged: , , , , , , , , , , .

The name of the blog  is inspired by two neurotrophic factors. The first one: GDNF or Glial cell-derived neurotrophic factor is a neurotrophic factor that play key roles in the control of growth and differentiation of the dopamin neuron, and as an potent survival factor for dopaminergic, noradrenergic and spinal motor neurons. In Parkinson’s  disease the results have been mixed, but some results are fantastic.

GDNF and the Amgen trial.


Anti-Addicive effect of GDNF

The antiaddictive effects of Ibogaine is mediated by GDNF in the ventral tegmental area. Researchers found that GDNF infusion very rapidly and dose-dependently reduced rat ethanol, self-administration:

Importantly, we demonstrate that GDNF infused into the VTA alters rats’ responses in a model of relapse. Specifically, GDNF application blocked reacquisition of ethanol self-administration after extinction. Together, these results suggest that GDNF, via activation of the MAPK pathway, is a is a fast-acting selective agent to reduce the motivation to consume and seek alcohol. fast-acting selective agent to reduce the motivation to consume and seek alcohol. (1)

we showed that the sustaineda ctions of ibogaine are mediated via an autoregulatory positive feedback loop in which GDNF triggers its own expression.

    Ibogaine have been used to cure addictions from:Heroin, Morphine, Methadone and Painkillers.

The Root of Hope – Ibogaine – Begreppseken

Could the answer to America’s drug problem lie in an African root? Supporters say Ibogaine can treat Oxycontin, Vicodin, alcohol and heroin addiction.

(1) GDNF is a fast-acting potent inhibitor of alcohol
consumption and relapse
Sebastien Carnicella, Viktor Kharazia, Jerome Jeanblanc, Patricia H. Janak, and Dorit Ron
The Ernest Gallo Research Center and †Department of Neurology, University of California at San Francisco, Emeryville, CA 94608
Edited by Hans Thoenen, Max Planck Institute of Neurobiology, Martinsried.

 

The importance of Drugs

Posted by gdnf on April 11, 2010
Posted in: Ibogaine. Tagged: , , , , , , , , , , , .

Maybe impressions from drugs and persons with visions have created al religions as we know them, have inspired countless artworks, musical escapades smash hits and countless tragic deaths. So to deny the importance of drugs in society seems to just create a state of denial.

But as drugs can inspire and sometimes help, we also have to realize something we can’t see, the dead ones and the addicts who take their last breath in this very moments. Those who standing beside the 99-years old woman who says -i have been smoking cigarettes al my life and drinking whiskey to. But how often can we really see the choir of persons standing beside them without any body at al? How often do we listen to the message from the true witnesses? They paid al they had and now they don’t even have a voice, shall we really listen to them?

The science of Antiaddiction

With that in mind, we could realize that drugs have it’s ups and downs and that there is an shure hell getting caught in severe addiction. Here you can find more scientific information about ibogaine.

Le origins du Monde, Ibogaine video at clipmoon with Deborah Mash.

  • 06:07 Ibogaine Root of hope

    Could the answer to America’s drug problem lie in an African root? Supporters say Ibogaine can treat Oxycontin, Vicodin, alcohol and heroin addiction. Some former drug addicts swear by it. Others warn it’s too dangerous. In this Special Assignment investigation, CBS 2’s Laura Diaz explores the “Root Of Hope”.

  • CAC News on Ibogaine Treatment 20 Feb, 2004 – BAY AREA (KRON 4) – Drug addiction has been the plague of modern America. But that could now change forever. What started as a rumor may now actually be an incredible breakthrough in the battle against addictions.

  • CBS-nyheterna rapporterar om iboagin 04:57 CBS-news

  • Ibogaine 10:22 Ibogaine

    The very last hope..

    Is there a life with heroin and methadone or is it just like Howard Lotsof said an emulation of Death?

Ibogaine in a bottle

Posted by gdnf on February 18, 2010
Posted in: Ibogaine. Tagged: , , , , , , , .

Clipmoon Kron 4 News: Ibogaine, Psycedelic Science – ibogaine.

The New York Times Howard Lotsof Dies at 66, died on Jan. 31 at a hospital near his home on Staten Island. The cause was liver cancer, his wife, Norma said.

…Virtually from that day 48 years ago when he first tried ibogaine, Mr. Lotsof became perhaps its leading advocate, lobbying public officials, pharmaceutical companies and independent researchers to investigate its efficacy. In the mid-1980s, he persuaded a Belgian company to manufacture ibogaine in capsule form and begin offering it to addicts in the Netherlands.

“His great achievement,” said Kenneth Alper, an associate professor of psychiatry and neurology at the New York University School of Medicine, “was in inducing the National Institute on Drug Abuse to undertake a research project on ibogaine that produced scores of peer-reviewed publications and paved the way for F.D.A. approval of a clinical trial.”

The Food and Drug Administration did approve the trial, Dr. Alper said, but it was never completed because of contractual disputes and lack of financing. Ibogaine remains banned by the federal government.

“In the uncontrolled environments in which ibogaine is typically used, clinics or nonmedical settings,” Dr. Alper said, “the observations indicate that there is a resolution of withdrawal, meaning the addict is detoxified and no longer has withdrawal symptoms and is no longer physically dependent.” Scientifically controlled testing is needed, he said.

Dutch video with Howard: A novel antiaddictice medication: ibogaine.